KRISP NEWS
We have been invited to give a keynote speech in the International Virus Bioinformatics Meeting (IVBM) 2020, Bern, Switzerland. IVBM 2020 is jointly organized by the European Virus Bioinformatics Center, the University of Bern and the Swiss Institute of Bioinformatics.
In today’s world, health and wellness are critical components of a productive work environment and a happy workforce. To often, these topics are misunderstood or ignored in an organisation’s drive for results and profit. Health and wellness can also not be viewed in isolation of each other, as each feeds into and supports the other. Health is a state of body, and wellness is a state of being
Prof. Frandsen, who published a paper in Science on conservation genomics in Nov 2019, has worked with KRISP & Genomics Africa to identify DNA sequencing services that we offer the conservation community in Africa.
This month, we focus on a key Nature Communications paper that report a 43% decline in the overall HIV incidence rate in northern KZN. We also hosted a leading conservation genomics scientist and organized many talks and events. We went to Drakensberg for our strategic meeting, released the KRISP Wellness program and even went to Hamburg, Germany, to compete in the finals of the Upgrade my NGS Competition.
At the end of November, the KRISP team traded their lab coats and laptops for hiking boots and hats, as they travelled up to the Sani Pass Premier Resort for a three-day strategy session
UKZN African Health Flagship Talks by Dr. Richard Lessells (KRISP UKZN & CAPRISA), Can we stop worrying about HIV drug resistance with the roll-out of dolutegravir? Tuesday, 26 Nov 2019 (12:00pm - 1:00pm), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!
KRISP at UKZN challenges the status quo to create a scientific environment in (South) Africa that delivers high level science, creates innovations and reverses the brain drain. This vision is starting to pay off, and we are happy to say that in just three years, we published > 100 papers, including fifteen (15) manuscripts in Nature, Science and Lancet journals!
UKZN African Health Flagship and KRISP Talks by Dr. Benjamin Chimukangara (Phd Graduation Talk, Post-Fellow at KRISP, UKZN) - Increasing levels of HIV pretreatment drug resistance in South Africa. Tuesday, 19 Nov 2019 (11:00am - 12:00), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!
The SAMRC, through its Strategic Health Innovation Partnership (SHIP) programme, is seeking to fund five highly collaborative projects in the areas of pharmacogenomics with reference to failure of treatments with drugs (or drug classes) for Non-Communicable diseases, specifically Hypertension, Cardiovascular, Diabetes and Cancer in (South) Africa. Total Budget ZAR 12-14 million, which genomics data generation should be done in a DIPLOMICS laboratory, such as KRISP, in South Africa.
This month, we focus on the art & science output of KRISP. This month we published many manuscripts including a key papers with CAPRISA that show a significant decline in HIV incidence in young women in KZN. We also participated in a large study that track HIV incidence in 10 African countries. We have also published a manuscript on the Ethics of HIV-1 molecular research and phylogenetics and worked with Brazilian collaborators to track the dissemination of viruses outbreaks in Brazil.
KRISP PAPERS
The pharmacokinetic properties of HIV-1 protease inhibitors: A computational perspective on herbal phytochemicals..
Kehinde I, Ramharack P, Nlooto M, Gordon M, Heliyon (2019), 5(10):e02565. doi: 10.1016/j.heliyon.2019.e02565:.
Analysis of the microarray gene expression for breast cancer progression after the application modified logistic regression.
Morais-Rodrigues F, Silv Erio-Machado R, Kato RB, Rodrigues DLN, Valdez-Baez J, Fonseca V, San EJ, Gomes LGR, Dos Santos RG, Vinicius Canário Viana M, da Cruz Ferraz Dutra J, Teixeira Dornelles Parise M, Parise D, Campos FF, de Souza SJ, Ortega JM, Barh D, Ghosh P, Azevedo VAC, Dos Santos MA, Gene (2019), 144168. doi: 10.1016/j.gene.2019.144168.:.
Declines in HIV incidence among men and women in a South African population-based cohort.
Vandormael A, Akullian A, Siedner M, de Oliveira T, Bärnighausen T, Tanser F, Nature Communications (2019), 10(1):5482. doi: 10.1038/s41467-019-13473-y:.
Undetectable proviral deoxyribonucleic acid in an adolescent perinatally infected with human immunodeficiency virus-1C and on long-term antiretroviral therapy resulted in viral rebound following antiretroviral therapy termination: A case report with implications for clinical care.
Koofhethile CK, Moyo S, Kotokwe KP, Mokgethi P, Muchoba L, Mokgweetsi S, Gaolathe T, Makhema J, Shapiro R, Lockman S, Kanki P, Essex M, Gaseitsiwe S, de Oliveira T, Novitsky V, Medicine (Baltimore) (2019), 98(47):e18014. doi: 10.1097/MD.0000000000018014:.
Trends in HIV Prevention, Treatment, and Incidence in a Hyperendemic Area of KwaZulu-Natal, South Africa
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Kharsany ABM, Cawood C, Lewis L, Yende-Zuma N, Khanyile D, Puren A, Madurai S, Baxter C, George G, Govender K, Beckett S, Samsunder N, Toledo C, Ayalew KA, Diallo K, Glenshaw M, Herman-Roloff A, Wilkinson E, de Oliveira T, Abdool Karim SS, Abdool Karim Q, JAMA Network Open (2019), 2(11):e1914378. doi:10.1001/jamanetworkopen.2019.14378:.
Yellow fever virus re-emergence and spread in Southeast Brazil, 2016-2019.
Giovanetti M, Lima de Mendonça MC, Fonseca V, Mares-Guia MA, Fabri A, Xavier J, Goes de Jesus J, Gräf T, Damasceno Dos Santos Rodrigues C, Cardoso Dos Santos C, Alves Sampaio S, Lowen Levy Chalhoub F, Bruycker Nogueira F, Theze J, Pecego Martins Romano A, Garkauskas Ramos D, Luiz de Abreu A, Kleber Oliveira W, do Carmo Said RF, Campelo de Alburque CF, de Oliveira T, Fernandes CA, Ferreira Aguiar S, Chieppe A, Carvalho Sequeira P, Rodrigues Faria N, Venâncio Cunha R, Alcantara LCJ, Bispo de Filippis AM., Journal of Virology (2019), JVI.01623-19. doi: 10.1128/JVI.01623-19:.
Recent levels and trends in HIV incidence rates among adolescent girls and young women in ten high-prevalence African countries: a systematic review and meta-analysis.
Birdthistle I, Tanton C, Tomita A, de Graaf K, Schaffnit SB, Tanser F, Slaymaker E, Lancet Global Health (2019), 7: e1521–40:.
KRISP VIDEOS
KRISP Public Engagement Photography Exhibition Lifeblood: A Showcase of African Diversity by Samora Chapman
By: Paul and Tulio de Oliveira
KRISP TEAM
KRISP BLOGS
KRISP TOOLS
2019-02-12
REGA HIV Subtyping Tool V3 - Belgium Mirror
Phylogenetic tool to identify the HIV-1 subtypes and recombinants. Query sequences are analysed for recombination using bootscanning methods. The version 3 contains new CRFs (CRF01_AE to CRF47_BF).
2018-12-05
Booster: a new bootstrap method for construction of large trees
A new version of the phylogenetic bootstrap in which the presence of inferred branches in replications is measured using a gradual 'transfer' distance rather than the binary presence or absence index used in Felsenstein's original version. The resulting supports are higher and do not induce falsely supported branches.
2016-08-21
REGA HIV Subtyping Tool V3 - South African mirror
This tool is designed to use phylogenetic methods in order to identify the HIV-1 subtype of a specific sequence. The sequence is analysed for recombination using bootscanning methods. The version 3 contains new CRFs (CRF01_AE to CRF47_BF).
2016-08-20
This is the first version of the Zika typing tool, which uses phylogenetic analysis to identify the species and genotype of the virus.
2016-08-20
This is the first version of our Arbovirus typing tool for Chikungunya, Dengue, Yellow Fever and Zika
2016-08-20
ArboTyping: Chikungunya Typing Tool
This is the first version of the Chikungunya typing tool, which uses phylogenetic analysis to identify the species and genotype of the virus.