From NGS data to real-time tracking of viruses' outbreaks: NextStrain and Genome Detective workshop. KRISP, Nelson Mandela School of Medicine, UKZN, Durban, South Africa, 24-25 January. Training is free to post-graduate students of UKZN and members of the H3AbioNet Bioinformatics Network.
KRISP & Thermo Seminar and Lab Tour qPCR Solutions for Infectious Disease Seminar, 11 December 2018 (9:30 - 11:30), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!
KRISP Talks by Dr Sikhulile Moyo & Dr Catherine Koofhethile, Harvard School of Public Health & Botswana Harvard Partnership (BHP), 10 December 2018 (11:00 - 12:00), K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!
KRISP at UKZN partner with Stanford University on a global innovation program: SPARK GLOBAL: Translational Scientists without borders. As part of this program we run a monthly meeting (first Wednesday of EVERY MONTH) to discuss innovation, select and mentor start-ups that can produce translational research.
Durban SPARK Innovation Breakfast by Barlow Manilal, CEO TIA, Wednesday, 7 November 2018 (7:30am - 8:30), KRISP, K-RITH building, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa. All welcome!
This month, we focused our newsletter on KRISP learning about new technologies and preparing the next generation of scientists. This month, we also have many publications on African Health, including on HIV drug resistance, antimicrobial activity, pre-eclampsia and smoking and depression.
KRISP Faculty teach Health Measurement Descriptive course at School of Nursing and Public Health. The aim of the course is to provide learners with skills to collect, analyse and use health information. In addition, this course provide students with an understanding of the basic principles and methods of descriptive epidemiology, descriptive biostatistics and demography.
Community engagement with HIV drug adherence in rural South Africa: a transdisciplinary approach.
Treffry-Goatley A, Lessells RJ, Moletsane R, de Oliveira T, Gaede B, BMJ Med Humanit (2018), 44:239–246.
HIV drug resistance in sub-Saharan Africa: public health questions and the potential role of real-world data and mathematical modelling.
de waal R, Lessells R, Hauser A, Kouyos R, Davies M-A, Egger M, Wandeler G, for ieDeA-Southern Africa, Journal of Virus Eradication (2018), 4(Supplement 2): :55–58.
Predicted antiviral activity of tenofovir versus abacavir in combination with a cytosine analogue and the integrase inhibitor dolutegravir in HIV-1-infected South African patients initiating or failing first-line ART.
Derache A, Iwuji CC, Danaviah S, Giandhari J, Marcelin AG, Calvez V, de Oliveira T, Dabis F, Pillay D, Gupta RK, J Antimicrob Chemother. (2018), doi: 10.1093/jac/dky428:doi:10.1093/jac/dky428.
Genomic and epidemiological monitoring of yellow fever virus transmission potential.
Faria NR, Kraemer MUG, S C Hill, J Goes de Jesus, R S Aguiar, F C M Iani, J Xavier, J Quick, L du Plessis, S Dellicour, J Thézé, R D O Carvalho, G Baele, C-H Wu, P P Silveira, M B Arruda, M A Pereira, G C Pereira, J Lourenço1, U Obolski, L Abade, T I Vasylyeva, M Giovanetti, D Yi, D J Weiss, G R W Wint, F M Shearer, S Funk, B Nikolay, Fonseca V, T E R Adelino, M A A Oliveira, M V F Silva, L Sacchetto, P O Figueiredo, I M Rezende, E M Mello, R F C Said, D A Santos, M L Ferraz, M G Brito, L F Santana, M T Menezes, R M Brindeiro, A Tanuri, F C P dos Santos, M S Cunha, J S Nogueira, I M Rocco, A C da Costa, S C V Komninakis, V Azevedo, A O Chieppe, E S M Araujo, M C L Mendonça, C C dos Santos, C D dos Santos, A M Mares-Guia, R M R Nogueira, P C Sequeira, R G Abreu, M H O Garcia, A L Abreu, O Okumoto, E G Kroon, C F C de Albuquerque, K Lewandowski, S T Pullan, M Carroll, de Oliveira T, E C Sabino, R P Souza, M A Suchard, P Lemey, G S Trindade, B P Drumond, A M B Filippis, N J Loman, S Cauchemez, Alcantara LCJ, Pybus OG , Science (2018), DOI: 10.1126/science.aat7115:.
Genome Detective: An Automated System for Virus Identification from High-throughput sequencing data..
Vilsker M, Moosa Y, Nooij S, Fonseca V, Ghysens Y, Dumon K, Pauwels R, Alcantara LC, Vanden Eynden E, Vandamme AM, Deforche K, de Oliveira T, Bioinformatics (2018), doi: 10.1093/bioinformatics/bty695:.
Patterns of genomic site inheritance in HIV-1M inter-subtype recombinants delineate the most likely genomic sites of subtype-specific adaptation.
Tongo M, de Oliveira T, Martin DP, Virus Evolution (2018), Volume 4, Issue 1, 1 January 2018, vey015:.
Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research.
Dorward J, Lessells R, Drain PK, Naidoo K, de Oliveira T, Pillay Y, Karim SSA, Garrett N, Lancet HIV (2018), https://doi.org/10.1016/S2352-3018(18)30093-6:.
STEM Education in Africa: KRISP & Thermo Fisher Scientific PCR Workshops
By: Deseree Rajpal, Sahil Tulsi, Veron Ramsuran, Jennifer Giandhari, Nicolette Crozier and Tulio de Oliveira
A new version of the phylogenetic bootstrap in which the presence of inferred branches in replications is measured using a gradual 'transfer' distance rather than the binary presence or absence index used in Felsenstein's original version. The resulting supports are higher and do not induce falsely supported branches.
This tool is designed to use phylogenetic methods in order to identify the HIV-1 subtype of a specific sequence. The sequence is analysed for recombination using bootscanning methods. The version 3 contains new CRFs (CRF01_AE to CRF47_BF).
This is the first version of the Zika typing tool, which uses phylogenetic analysis to identify the species and genotype of the virus.
This is the first version of our Arbovirus typing tool for Chikungunya, Dengue, Yellow Fever and Zika
This is the first version of the Chikungunya typing tool, which uses phylogenetic analysis to identify the species and genotype of the virus.
This is the first version of the Yellow Fever typing tool, which uses phylogenetic analysis to identify the species and genotype of the virus.