About Dr. Siva Danaviah

sdanaviah@africacentre.ac.za +27 (0) 31 260 3744

Background

Siva Danaviah received a PhD from University of KwaZulu-Natal in 2009 with training in Molecular Virolgy and Bioinformatics. My doctoral research on the Immunopathogenesis of TB Spondylitis in HIV-Infected and -uninfected patients, suggested viral compartmentalization in the isolated spinal TB granuloma, which was a novel finding. The study also highlighted the need for a more sensitive, broad-range molecular diagnostic tool for pauci-bacillary diseases such as spinal TB. My investigation of T-cell proliferation in spinal TB granulomas of HIV-infected and -uninfected patients indicated a greater role of CD8 T-cells in the site specific immune response in CD4 depleted / immunosuppressed patients.



Publications

CD4+ T-cell count may not be a useful strategy to monitor antiretroviral therapy response in HTLV-1/HIV co-infected patients.
Vandormael A, Rego F, Danaviah S, Alcantara L, Boulware D, de Oliveira T, Current HIV Research (2017), :doi: 10.2174/1570162X15666170216114917.


HIV drug resistance levels in adults failing first-line antiretroviral therapy in an urban and a rural setting in South Africa.
Rossouw TM, Nieuwoudt M, Manasa J, Malherbe G, Lessells RJ, Pillay S, Danaviah S, Mahasha P, van Dyk G, de Oliveira T, HIV Med. (2017), 2016 :doi: 10.1111/hiv.12400.


Increasing HIV-1 drug resistance between 2010 and 2012 in adults participating in population-based HIV surveillance in rural KwaZulu-Natal South Africa.
Manasa J, Danaviah S, Lessells RJ, Elshareef M, Tanser F, Wilkinson E, Pillay S, Mthiyane H, Mwambi H, Pillay D, de Oliveira T, AIDS Res Hum Retroviruses (2016), 32(8):763-769.


Analysis of Dominant HIV Quasispecies Suggests Independent Viral Evolution Within Spinal Granulomas Coinfected with Mycobacterium tuberculosis and HIV-1 Subtype C.
Danaviah S, de Oliveira T, Gordon M, Govender S, Chelule P, Pillay S, Naicker T, Cassol S, Ndung'u T, AIDS Research and Human Retroviruses (2016), :doi:10.1089/aid.2015.0189.


Evidence of Long-Lived Founder Virus in Mother-to-Child HIV Transmission.
Danaviah S, de Oliveira T, Bland R, Viljoen J, Pillay S, Tuaillon E, Van de Perre P, Newell ML, PLoS One (2015), 10(3):e0120389.


Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa.
Manasa J, Lessells R, Rossouw T, Naidu K, Van Vuuren C, Goedhals D, van Zyl G, Bester A, Skingsley A, Stott K, , Database (Oxford) (2014), Vol. 2014 :bat082. doi: 10.1093/database/bat082.


Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort.
Pillay S, Bland RM, Lessells RJ, Manasa J, de Oliveira T, Danaviah S., AIDS Res Ther. (2014), 11(1):3. doi: 10.1186/1742-6405-11-3.


An Affordable HIV-1 Drug Resistance Monitoring Method for Resource Limited Settings.
Manasa J, Danaviah S, Pillay S, Padayachee P, Mthiyane H, Seebregts C, Rinke De Wit TF, Viljoen J, Katzenstein D, De Oliveira T , Journal of Visualized Experiments (JoVE) (2014), (85):e51242, doi:10.3791/51242.


A qualitative and quantitative histopathological analysis of the host immune response to TB of the spine in HIV-positive and negative patients.
Danaviah S, Sacks J, Taylor L, Govender S, Fallows D, Kumar KPS, Ndung'u T, Kaplan G. , Tuberculosis (2013), 93(4):432-41.


Pili contribute to biofilm formation in vitro in Mycobacterium tuberculosis.
Ramsugit S, Guma S, Pillay B, Jain P, Larsen MH, Danaviah S, Pillay M., Antonie Van Leeuwenhoek (2013), 104(2):DOI 10.1007/s10482-013-9981-6.


Cumulative exposure to cell-free HIV in breast milk, rather than feeding pattern per se, identifies postnatally infected infants.
Neveu D, Viljoen J, Bland RM, Nagot N, Danaviah S, Coutsoudis A, Rollins NC, Coovadia HM, Van de Perre P, Newell ML. , Clin Infect Dis (2011), 52(6):819-25.


Use of dried blood spots for the determination of genetic variation of IL-10, Killer Immunoglobulin-like Receptor and HLA Class I genes.
Ndlovu BG, Danaviah S, Moodley E, Ghebremichael M, Bland R, Viljoen J, Newell M-L, Ndung'u T, and Carr WH, Tissue Antigens (2011), 79(2):114-22.


Comparison of the Generic HIV Viral Load assay with the Amplicor HIV-1 monitor v1.5 and Nuclisens HIV-1 EasyQ v1.2 techniques for plasma HIV-1 RNA quantitation of non-B subtypes: the Kesho Bora preparatory study. .
Rouet F, Foulongne V, Viljoen J, Steegen K, Becquart P, Valea D, Danaviah S, Segondy M, Verhofstede C, Van de Perre P; WHO/ANRS 1289 Kesho Bora Study Group, Virol Methods (2010), 163(2):253-7.


Dried Blood Spot HIV-1 RNA Quantification Using Open Real-Time Systems in South Africa and Burkina Faso.
Viljoen J, Gampini S, Danaviah S, Valea D, Pillay S, Kania D, Meda N, Newell ML, Van de Perre P, Rouet F; for the World Health Organization/ANRS 1289 Kesho Bora Study Group, Acquir Immune Defic Syndr (2010), 55(3):290-8.


In-house HIV-1 RNA real-time reverse transcription PCR assays: principle, available tests and usefulness in developing countries.
Rouet F, Menan H, Viljoen J, Ngo Giang Huong N, Mandaliya K, Valea D, Xuan L, Danaviah S, Rousset D, Ganon A and Nerrienet E, Expert Review of Molecular Diagnostics (2008), 8(5):635-650.


Atypical mycobacterial spondylitis in HIV-negative patients identified by 16S rDNA genotyping.
Danaviah S, Govender S, Gordon ML, Cassol S. , J Bone Joint Surg Br. (2007), 89(3) :346-348.


Cervical spine tuberculosis in children.
Govender S, Ramnarain A, Danaviah S, Clin Orthop Relat Res. (2007), 460:50-5.


A report of 3 unusual opportunistic bacterial infections of the spine.
Danaviah S, Govender S, Gordon M, Cassol S, SAOJ (2006), 5(3):12-16.


BioAfrica's HIV-1 proteomics resource: combining protein data with bioinformatics tools.
Doherty RS, de Oliveira T, Seebregts C, Danaviah S, Gordon M, Cassol S, Retrovirology (2005), 2:18.


Prevalence, incidence and mother-to-child transmission of HIV-1 in rural South Africa.
Rollins NC, Dedicoat M, Danaviah S, Page T, Bishop K, Kleinschmidt I, Coovadia HM, Cassol SA, Lancet (2002), 360(9330):389.



KRISP Blogs from Bioafrica and SATuRN websites