Title: HIV & TB Drug Resistance & Clinical Management Case Book
Authors: Rossouw T, Lessells RJ, de Oliveira T.
Journal: South African Medical Research Council Press,ISBN 978-1-920014-91-9: (2013)


The twin epidemics of HIV and TB continue to cause untold damage to individuals, families and communities in sub-Saharan Africa. The massive scale up of antiretroviral therapy (ART) in this region has begun to reverse some of the trends in morbidity and mortality caused by these twin epidemics. Drug resistance appears as an inevitable consequence of the widespread use of antimicrobial agents. The past two decades has seen the emergence of drug-resistant strains of Mycobacterium tuberculosis which threaten basic TB control. Resistance to antiretroviral drugs is now an escalating threat in this region as we end the first decade of ART roll-out in Africa with over five million people receiving ART.

In order to confront this challenge we need to learn how to prevent and manage drug resistance, both at an individual and at a programmatic level. The aim of this book is to equip health care workers with the knowledge and skills to diagnose and manage cases of drug-resistant HIV and TB but also to learn how drug resistance might be prevented. The focus is on the interpretation of diagnostic tests related to drug resistance. The book is aimed primarily at doctors, nurses, and pharmacists but other readers might find information that is relevant for their own circumstances. The focus throughout most of the cases is on practice in the public health sector but there is also information relevant to private practitioners.

The book is equally suited to learning on your own or learning within a group - the cases could, for example, be used as teaching material for Nurse Initiation and Management of ART (NIM-ART) nurses at your clinic or hospital. The cases are also available online ( - new cases will be added regularly to the online site and updated information about existing cases will also be added. We aim to compile a second edition of this book in the future as more cases are added to the website.

It has been a great pleasure putting together this book and we hope that you also enjoy the experience of reading and learning from the material. We ask that readers send us any feedback and comments so that we can improve the book in future editions. You can send your comments to us using our email addresses.

Theresa Rossouw MBChB, PhD, MPH

Richard J Lessells BSc(MedSci), MBChB, MRCP(UK), DTM&H, DipHIVMed

Tulio de Oliveira BSc, BSc (Hon), PhD

The HIV & TB Drug Resistance Clinical Management Case Book is free for download at our website


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Short interview about our HIV & TB Drug Resistance & Clinical Management Case Book

For more videos please visit BioAfrica & SATuRN YouTube Channel

Printed and Online Media Coverage


HIV/TB Drug Resistance and Clinical Management Workshop & Book Launch, Ghost Mountain Inn, Mkuze, South Africa, 7-8 Mar 2013SATuRN - 2013-02-18

Organised by the Africa Centre for Health and Population Studies and Southern African Treatment and Resistance Network (SATuRN) in collaboration with the uMkhanyakude District Health Office. This workshop is aimed at developing knowledge and skills around the prevention and management of drug resistance and treatment failure in both HIV and TB.

Africa Centre

PRESS RELEASE: Book Launch: HIV and TB Drug Resistance & Clinical Management Case BookAfrica Centre - 2013-03-06

Prof Eric Buch, Dean of the Faculty of Health Sciences at the University of Pretoria, in partnership with European Delegation to South Africa, MRC Inflammation and Immunity Unit and the Africa Centre for Health and Population Studies, UKZN, invite members of the media to attend the launch of the 'HIV and TB Resistance & Clinical Management Case Book' that is authored by Dr Theresa Rossouw of UP and Drs Richard Lessells and Tulio de Oliveira of the Africa Centre for Health and Population Studies. The details are as follows:

University of Pretoria

Invitation to the launch of the HIV and TB drug resistance & clinical management case bookUniversity of Pretoria - 2013-03-05

University of Pretoria invites you to attend the launch of the publication HIV and TB resistance & clinical management case book. The invitation is writen in three official South African languages: Afrikaans, English and Sepedi.


Transferring Critical Knowledge and Skills to Frontline Medical Personnel Fighting the HIV & TB epidemics in rural South AfricaUKZN - 2013-03-15

UKZN's Africa Centre for Health and Population Studies, based in the College of health Sciences, has once again made huge strides in HIV management. Recently, the Centre's, Dr Richard Lessells and Dr Tulio de Oliveira together with the University of Pretoria's, Dr. Theresa Rossouw; launched a book entitled, 'HIV and TB: Drug Resistance and Clinical Management Case Book'.



HIV and TB: Drug Resistance and Clinical Management Case Book - a book co-authored by two academics from the Africa Centre for Health and Population Studies - has been presented to frontline health workers at a workshop in northern KwaZulu-Natal.

University of Pretoria

University of Pretoria and partners launch a bookUniversity of Pretoria - 2013-03-19

By Sanku Tsunke, Pretoria, 19 March 2013. Drug resistance is one of the main challenges confronting HIV and TB programmes in Africa. Facing these challenges requires an understanding of how drug resistance develops, as well as up-to-date knowledge of how to diagnose and manage drug resistance in HIV and TB patients.

Universiteit van Pretoria

Universiteit van Pretoria en vennote stel boek vry oor weerstand teen middels wat gebruik word om MIV en tuberkulose te bekampUniversiteit van Pretoria - 2013-03-15

Weerstand teen medikasie is een van die belangrikste struikelblokke wat programme om MIV en tuberkulose in Afrika te bestry te bowe moet kom. Om hierdie uitdagings die hoof te bied, word 'n begrip vereis van hoe weerstand teen die middels tot stand kom, sowel as vertroudheid met die jongste metodes om weerstand teen die medikasie in MIV- en tuberkulosepasiente te diagnoseer en bestuur.


Casebook aims to curb drug resistancePretoriaNews - 2013-03-19

Pretoria News - 19 March 2013, DOCTORS from the University of Pretoria (UP) and University of KwaZulu-Natal (UKZN) have stepped up to the challenge of providing a clinical management casebook for health care workers treating patients with HIV and TB drug resistance.


SATuRN will have a session at the 17th Rural Health ConferenceRUDASA - 2013-03-31

The 17th Annual Rural Health Conference will be held in St. Lucia, KwaZulu-Natal, South Africa, from 8 to 10 August 2013. SATuRN will have a session (approximately 2-3 hours) in the conference and will distribute the HIV & TB Drug Resistance and Clinical Management Case Book.

Zululand Observer

Case book tackles HIV and TB drug resistanceZululand Observer - 2013-04-15

By Jonathan Davis, 15 April 2013 - Researchers from the Africa Centre for Health and Population Research near Mtubatuba have published a important book to help rural doctors, nurses and pharmacists working on the frontline of the country's interlinked HIV and tuberculosis (TB) pandemics manage increasing levels of resistance to the drugs needed to fight the diseases.

Southern African Journal of HIV Medicine

BOOK REVIEW - HIV & TB Drug Resistance & Clinical Management Case BookSouthern African Journal of HIV Medicine - 2013-06-20

by Sigaloff & Hamers, The Southern African Journal of HIV Medicine, Book Review on the HIV & TB Drug Resistance & Clinical Management Case Book by Rossouw, Lessells and de Oliveira

SATuRN/BioAfrica Reports on this Publication

SATuRN and Khethimpilo HIV Drug Resistance and Clinical Management Workshop Report, Durban, 11-12 July 2013

SATuRN 2013 report, date: 2013-08-01

Dean Solomon and Tulio de Oliveira