Title: Investigation of the N-Terminus Amino Function of Arg10-Teixobactin
Authors: Monaim SAHA, Noki S, Ramchuran EJ, El-Faham A, Albericio F, Torre BG.
Journal: Molecules,22(10):doi: 10.3390/molecules22101632 (2017)
Teixobactin is a recently described antimicrobial peptide that shows high activity against gram-positive bacteria as well as mycobacterium tuberculosis. Due to both its structure as a head-to-side chain cyclodepsipeptide and its activity, it has attracted the attention of several research groups. In this regard, a large number of analogs with substitutions in both the cycle and the tail has been described. Here, we report the contribution of the N-terminus residue, N-Me-d-Phe, to the activity of Arg10-teixobactin. On the basis of our findings, we conclude that the N-terminus accepts minimum changes but not the presence of long alkyl chains. The presence of a positive charge is a requirement for the activity of the peptide. Furthermore, acylation of the N-terminus leads to total loss of activity.
Citation: Monaim SAHA, Noki S, Ramchuran EJ, El-Faham A, Albericio F, Torre BG. Investigation of the N-Terminus Amino Function of Arg10-Teixobactin Molecules,22(10):doi: 10.3390/molecules22101632 (2017).
KRISP has been created by the coordinated effort of the University of KwaZulu-Natal (UKZN), the Technology Innovation Agency (TIA) and the South African Medical Research Countil (SAMRC).