Title: Investigating Triorthogonal Chemoselectivity. Effect of Azide Substitution on the Triazine Core.
Authors: Sharma A, Sheyi R, Kumar A, El-Faham A, de la Torre BG, Albericio F..
Journal: Org Lett., doi: 10.1021/acs.orglett.9b02878: (2019)
An example of triorthogonal chemoselectivity is reported here for the first time. In this regard, a series of 43 reactions were performed using tridentate s-triazine as a model. In all of the possible cases, the three substitutions were carried out using different nucleophiles at a temperature compatible with biological systems.