About Dr. Richard Lessells

rjlessells@gmail.com +27 31 260 4898

Background

I am a Clinical Research PhD Graduate from the London School of Hygiene and Tropical Medicine and am currently based at the Africa Centre for Health and Population Studies. I was funded by a fellowship from the Wellcome Trust and my research is focused on evaluation of TB and HIV diagnostics, with a particular interest in drug resistance.

Affiliations:

Group Leader: KRISP - KwaZulu-Natal Research and Innovation Sequencing Platform, UKZN, Durban, South Africa.

Associate: Centre for the AIDS Programme of Research in South Africa Advanced Clinical Care (CAPRISA ACC), Durban, South Africa.

Associate: Infectious Diseases Department, Nelson R Mandela School of Medicine, UKZN, Durban, South Africa.



Publications

Dolutegravir for first-line antiretroviral therapy in low-income and middle-income countries: uncertainties and opportunities for implementation and research.
Dorward J, Lessells R, Drain PK, Naidoo K, de Oliveira T, Pillay Y, Karim SSA, Garrett N, Lancet HIV (2018), http://dx.doi.org/10.1016/ S2352-3018(18)30093-6:.


Spatial clustering of drug-resistant tuberculosis in Hlabisa subdistrict, KwaZulu-Natal, 2011-2015.
Smith CM, Lessells R, Grant AD, Herbst K, Tanser F, Int J Tuberc Lung Dis. (2018), 1;22(3):287-293. doi: 10.5588/ijtld.17.0457:.


Tuberculosis mortality and the male survival deficit in rural South Africa: An observational community cohort study.
Reniers G, Blom S, Lieber J, Herbst AJ, Calvert C, Bor J, Barnighausen T, Zaba B, Li ZR, Clark SJ, Grant AD, Lessells R, Eaton JW, Hosegood V, PLoS ONE (2017), 12(10):e0185692. doi: 10.1371/journal.pone.0185692:.


HIV assessment and testing for hospital in-patients: still a weak link in the cascade.
Iwuji CC, Lessells RJ, Public Health Action (2017), 21;7(4):243. doi: 10.5588/pha.17.0111:.


Impact of point-of-care Xpert MTB/RIF on tuberculosis treatment initiation: a cluster randomised trial.
Lessells RJ, Cooke GS, McGrath N, Nicol MP, Newell ML, Godfrey-Faussett P, Am J Respir Crit Care Med (2017), :doi: 10.1164/rccm.201702-0278OC.


HIV drug resistance levels in adults failing first-line antiretroviral therapy in an urban and a rural setting in South Africa.
Rossouw TM, Nieuwoudt M, Manasa J, Malherbe G, Lessells RJ, Pillay S, Danaviah S, Mahasha P, van Dyk G, de Oliveira T, HIV Med. (2017), 2016 :doi: 10.1111/hiv.12400.


Increasing HIV-1 drug resistance between 2010 and 2012 in adults participating in population-based HIV surveillance in rural KwaZulu-Natal South Africa.
Manasa J, Danaviah S, Lessells RJ, Elshareef M, Tanser F, Wilkinson E, Pillay S, Mthiyane H, Mwambi H, Pillay D, de Oliveira T, AIDS Res Hum Retroviruses (2016), 32(8):763-769.


Understanding Specific Contexts of Antiretroviral Therapy Adherence in Rural South Africa: A Thematic Analysis of Digital Stories from a Community with High HIV Prevalence.
Treffry-Goatley A, Lessells R, Sykes P, Barnighausen T, de Oliveira T, Moletsane R, Seeley J., PLoS One (2016), 11(2):doi: 10.1371/journal.pone.0148801.


HIV treatment cascade in tuberculosis patients.
Lessells RJ, Swaminathan S, Godfrey-Faussett P, Curr Opin HIV AIDS (2015), 10(6):439-46. doi: 10.1097/COH.0000000000000197:.


Southern African Treatment Resistance Network (SATuRN) RegaDB HIV drug resistance and clinical management database: supporting patient management, surveillance and research in southern Africa.
Manasa J, Lessells R, Rossouw T, Naidu K, Van Vuuren C, Goedhals D, van Zyl G, Bester A, Skingsley A, Stott K, , Database (Oxford) (2014), Vol. 2014 :bat082. doi: 10.1093/database/bat082.


Drug resistance in children at virological failure in a rural KwaZulu-Natal, South Africa, cohort.
Pillay S, Bland RM, Lessells RJ, Manasa J, de Oliveira T, Danaviah S., AIDS Res Ther. (2014), 11(1):3. doi: 10.1186/1742-6405-11-3.


HIV & TB Drug Resistance & Clinical Management Case Book.
Rossouw T, Lessells RJ, de Oliveira T, South African Medical Research Council Press (2013), ISBN 978-1-920014-91-9:.


Are subtype differences important in HIV drug resistance?.
Lessells RJ, Katzenstein DK, de Oliveira T, Current Opinion Virology (2012), 2(5):636-43.


Gender Differences in Survival among Adult Patients Starting Antiretroviral Therapy in South Africa: A Multicentre Cohort Study.
Cornell M, Schomaker M, Garone DB, Giddy J, Hoffmann CJ, Lessells R, Maskew M, Prozesky H, Wood R, Johnson LF, Egger M, Boulle A, Myer L For IeDEA-SA, PLoS Medicine (2012), 9(9):e1001304.


Cohort profile: Hlabisa HIV Treatment and Care Programme.
Houlihan C, Bland R, Mutevedzi P, Lessells R, Ndirangu J, Thulare H, Newell ML, Int J Epidemiol (2011), 40:318-26.


Retention in HIV care for individuals not yet eligible for antiretroviral therapy: rural KwaZulu-Natal, South Africa.
Lessells RJ, Mutevedzi PC, Cooke GS, Newell ML., J Acquir Immune Defic Syndr (2011), 56(3):e79-86.


Poor long-term outcomes for cryptococcal meningitis in rural South Africa.
Lessells RJ, Mutevedzi PC, Heller T, Newell ML, S Afr Med (2011), 101:251-2.


International spread of multidrug-resistant tuberculosis from Tugela Ferry, South Africa.
Cooke GS, Beaton RK, Lessells RJ, John L, Ashworth S, Kon OM, Williams OM, Supply P, Moodley P, Pym AS, Emerg Infect Dis (2011), 17:2035-2037.


Evaluation of tuberculosis diagnostics: establishing an evidence base around the public health impact.
Lessells RJ, Cooke GS, Newell ML, Godfrey-Faussett P, J Infect Dis (2011), 204:S1187-95.


Community-based treatment for multidrug-resistant tuberculosis in rural KwaZulu-Natal, South Africa.
Heller T, Lessells RJ, Wallrauch C, Barnighausen T, Cooke GS, Mhlongo L, Master I, Newell ML, Int J TB Lung Dis (2010), 14:420-426.


The TB challenge in a rural South African HIV programme.
Houlihan C, Mutevedzi P, Lessells R, Cooke G, Tanser F, Newell ML, BMC Infect Dis (2010), 10:23.


HIV and hepatitis B co-infection in Africa.
Lessells RJ, Main J, Cooke GS, Lancet Infectious Diseases (2008), 8:210-11.



KRISP Blogs from Bioafrica and SATuRN websites

Blogs


KRISP News Section from Bioafrica and SATuRN websites

News

BOOK REVIEW - HIV & TB Drug Resistance & Clinical Management Case Book - Southern African Journal of HIV Medicine - 2013-06-20


University of Pretoria and partners launch a book - University of Pretoria - 2013-03-19


Casebook aims to curb drug resistance - PretoriaNews - 2013-03-19


The Machine That Will Help End TB - MIT Technology review - 2012-12-11


BioAfrica Art & Science section is open! - BioAfrica - 2012-05-10