The tainted milk of human kindness. Lancet, 380: 702 (2012).

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Title: The tainted milk of human kindness
Authors: Goedhals D, Rossouw I, Hallbauer U, Mamabolo M, de Oliveira T.
Journal: Lancet,380:702 (2012)

Journal Impact Factor (I.F.): 33.633
Number of citations (Google Scholar): 5

Abstract

In September, 2009, a 74-day-old infant presented to a local hospital in Bloemfontein, South Africa, in broncho- pneumonia related respiratory distress. She appeared pale, cyanosed, and had palpable axillary lymph nodes, hepatomegaly, and oropharyngeal candidosis. She had received all scheduled vaccinations and had been exclusively breastfed. Cytomegalovirus was isolated from a respiratory sample by shell vial culture, and a paired blood sample showed a cytomegalovirus viral load of 12 600 copies per mL. She was positive for HIV by ELISA and DNA PCR. However, the baby?s mother said that she tested HIV negative during pregnancy, which was confirmed by fourth generation ELISA test. The baby?s CD4 cell count was 2189 cells per mL (40% lymphocytes) and antiretroviral therapy was started. The mother reported that her sister had breastfed the baby inter- mittently from 6 weeks of age. The sister and her 5-month-old child were subsequently found to be HIV positive by ELISA and DNA PCR. Laboratory records confirmed the sister's positive HIV status in February, 2008, excluding recent seroconversion. At final follow-up in April, 2010, our patient was well with an undetectable HIV viral load.

Plasma samples from the sister and both infants were used for partial sequencing of the HIV pol gene with the TRUGENE HIV-1 genotyping kit (Siemens Healthcare Diagnostics, Tarrytown, NY, USA). We analysed the data with the same approach used to identify the source of the nosocomial HIV-1 CRFO2_AG outbreak in the Al-Fateh Hospital, Libya.1 We collated 100 HIV-1 reference strains from the Free State Province, South Africa, closely related to the three case sequences, and then estimated and assessed phylogenies using algorithmic, Bayesian, and maximum-likelihood methods. The case sequences form a well-supported monophyletic cluster within the HIV-1 subtype C clade. The linkage is supported with 100% bootstrap in the algorithm and maximum-likelihood methods and with 100% posterior probability in the Bayesian phylogenies.

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Citation: Goedhals D, Rossouw I, Hallbauer U, Mamabolo M, de Oliveira T. The tainted milk of human kindness Lancet,380:702 (2012).

Printed and Online Media Coverage

SABC

Breastfeeding in the spotlight

SABC - 2012-08-16

A case where an aunt infected her niece with HIV through breastfeeding has drawn attention to feeding practices in South Africa. The case was published in the medical journal Lancet and highlighted the risk of HIV transmission from a surrogate carer, the Africa Centre for Health and Population Studies said today.


Wellcome Trust

DNA sequencing confirms HIV transmission through surrogate breastfeeding

Wellcome Trust - 2012-08-23

DNA sequencing has provided evidence of HIV-1 transmission from an infected woman breastfeeding her niece in South Africa, drawing attention to infant feeding practices and the need for HIV testing of all breastfeeding surrogates as well as mothers.


Cape Argus

'Tainted milk' from wet nurse HIV risk

Cape Argus - 2012-08-26

By BIANCA CAPAZORIO - A BABY girl who contracted HIV after being breast-fed by a well-meaning aunt has become the first proven case in SA to have contracted HIV from a surrogate feeder or 'wet nurse'.


Zululand Observer

Local centre proves 'surrogate' HIV infection

Zululand Observer - 2012-08-24

The Africa Centre for Health and Population Studies, Zululand's HIV-AIDS research hub based near Mtubatuba, has revealed the first proven HIV surrogate transmission case in South Africa.


SA DoH research brief

Tainted Milk from Surrogate Feeder

SA DoH research brief - 2012-08-25

A baby girl who contracted HIV after being breast-fed by a well-meaning aunt has become the first proven case in South Africa to have contracted HIV from a surrogate feeder or 'wet nurse'. The case contained in new research highlights the importance of HIV testing of mothers and surrogate feeders at a time when the government is phasing out free infant formula in its clinics.



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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), K-RITH Tower Building, Nelson R Mandela School of Medicine, UKZN

Contact: Prof. Tulio de Oliveira, Tel: +27 31 260 4898, Email: tuliodna@gmail.com & deoliveira@ukzn.ac.za

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