Brief Report: Virologic Monitoring Can Be a Cost-Effective Strategy to Diagnose Treatment Failure on First-Line ART. J Acquir Immune Defic Syndr., 71(4): 462?466 (2016).

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Title: Brief Report: Virologic Monitoring Can Be a Cost-Effective Strategy to Diagnose Treatment Failure on First-Line ART
Authors: Vandormael AM, Boulware DR, Tanser FC, Barnighuasen TW, Stott KE, de Oliveira T.
Journal: J Acquir Immune Defic Syndr.,71(4):462?466 (2016)

Journal Impact Factor (I.F.): 5.4
Number of citations (Google Scholar): 1

Abstract

CD4 count testing is perceived to be an affordable strategy to diagnose treatment failure on first-line ART. We hypothesize that the superior accuracy of viral load (VL) testing will result in less patients being incorrectly switched to more expensive and toxic second-line regimens. Using data from a drug resistance cohort, we show that CD4 testing is approximately double the cost to make one correct regimen switch under certain diagnostic thresholds (CD4=US$499 vs. VL=US$186 or CD4=US$3,031 vs. VL=US$1,828). In line with World Health Organization guidelines, our findings show that VL testing can be both an accurate and cost-effective treatment monitoring strategy.

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Citation: Vandormael AM, Boulware DR, Tanser FC, Barnighuasen TW, Stott KE, de Oliveira T. Brief Report: Virologic Monitoring Can Be a Cost-Effective Strategy to Diagnose Treatment Failure on First-Line ART J Acquir Immune Defic Syndr.,71(4):462?466 (2016).


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KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), K-RITH Tower Building, Nelson R Mandela School of Medicine, UKZN

Contact: Prof. Tulio de Oliveira, Tel: +27 31 260 4898, Email: tuliodna@gmail.com & deoliveira@ukzn.ac.za

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